{"census":{"archive_records":4830,"classifiable":2445593,"collection_total":5187265,"indexed":4403994,"recovered":783271,"share_of_census":3.58,"share_of_classifiable":6.44,"trials":157590,"undetermined":1958401},"challenge":{"controls":{"negative_failed_truth":9,"negative_passed_usual":9,"negative_total":9,"oracle_passed":9,"oracle_total":9},"groups":[{"id":"rotated_box","label":"Rotated box","passed_runs":1,"runs":[{"accepted":509,"attempts":8192,"ess":317.8406916888134,"failed_checks":[],"max_weight":0.014308585974925306,"passed":true,"region_error":0.04658344095924649,"seed":2026092501},{"accepted":450,"attempts":8192,"ess":221.09503440112093,"failed_checks":["maximum_weight","region_masses"],"max_weight":0.022265978005487484,"passed":false,"region_error":0.08226908949658907,"seed":2026092502},{"accepted":399,"attempts":8192,"ess":213.30286450271964,"failed_checks":["maximum_weight"],"max_weight":0.02716079102894785,"passed":false,"region_error":0.032860868663681264,"seed":2026092503}],"total_runs":3},{"id":"annular_cylinder","label":"Annular cylinder","passed_runs":3,"runs":[{"accepted":685,"attempts":8192,"ess":426.8471763399143,"failed_checks":[],"max_weight":0.007361501123457426,"passed":true,"region_error":0.03152416173173407,"seed":2026092511},{"accepted":727,"attempts":8192,"ess":514.8312640395712,"failed_checks":[],"max_weight":0.00862292899857793,"passed":true,"region_error":0.029273584328141894,"seed":2026092512},{"accepted":654,"attempts":8192,"ess":496.34867625505836,"failed_checks":[],"max_weight":0.0064578783972665844,"passed":true,"region_error":0.01320430846068446,"seed":2026092513}],"total_runs":3},{"id":"unequal_balls","label":"Unequal balls","passed_runs":3,"runs":[{"accepted":1526,"attempts":8192,"ess":1184.0660080608197,"failed_checks":[],"max_weight":0.002803702334487253,"passed":true,"region_error":0.008707228641733317,"seed":2026092521},{"accepted":1503,"attempts":8192,"ess":1162.8176266113717,"failed_checks":[],"max_weight":0.002906633454701523,"passed":true,"region_error":0.017062411277082856,"seed":2026092522},{"accepted":1511,"attempts":8192,"ess":1205.3159649837457,"failed_checks":[],"max_weight":0.002787829157241136,"passed":true,"region_error":0.02112470570411229,"seed":2026092523}],"total_runs":3}],"passed":false,"passed_runs":7,"thresholds":{"maximum_moment_error":0.05,"maximum_normalized_weight":0.02,"maximum_region_mass_error":0.075,"maximum_relative_mass_error":0.15,"maximum_relative_mcse":0.1,"minimum_accepted":20,"minimum_ess":200.0},"total_runs":9},"growth_period":{"end_year":2025,"start_year":2015},"mechanisms":[{"articles":6019,"growth":3.1,"id":"antibody-drug-conjugate","label":"Antibody–drug conjugates","top_partners":[{"articles":277,"id":"immunotherapy","label":"Immunotherapy"},{"articles":190,"id":"bispecific-antibody","label":"Bispecific antibodies"},{"articles":133,"id":"car-t","label":"CAR T-cell / adoptive therapy"},{"articles":106,"id":"nanoparticle","label":"Nanoparticles"},{"articles":35,"id":"synthetic-lethality","label":"Synthetic lethality"},{"articles":22,"id":"epigenetic","label":"Epigenetic processes & therapies"}],"top_sites":[{"articles":1083,"enrichment":4.42,"id":"lymphoma","label":"Lymphoma"},{"articles":971,"enrichment":2.06,"id":"breast","label":"Breast"},{"articles":219,"enrichment":1.75,"id":"ovary","label":"Ovary"},{"articles":135,"enrichment":1.58,"id":"bladder","label":"Bladder"},{"articles":124,"enrichment":0.98,"id":"pancreas","label":"Pancreas"},{"articles":344,"enrichment":0.91,"id":"lung","label":"Lung"}],"trial_share":9.64,"trials":580,"years":[[1957,1],[1992,3],[1993,3],[1994,28],[1995,49],[1996,61],[1997,44],[1998,53],[1999,65],[2000,59],[2001,70],[2002,82],[2003,67],[2004,56],[2005,59],[2006,52],[2007,70],[2008,60],[2009,70],[2010,57],[2011,107],[2012,129],[2013,147],[2014,154],[2015,235],[2016,237],[2017,275],[2018,318],[2019,312],[2020,350],[2021,420],[2022,434],[2023,462],[2024,624],[2025,729],[2026,77]]},{"articles":3462,"growth":5.52,"id":"bispecific-antibody","label":"Bispecific antibodies","top_partners":[{"articles":377,"id":"car-t","label":"CAR T-cell / adoptive therapy"},{"articles":235,"id":"immunotherapy","label":"Immunotherapy"},{"articles":190,"id":"antibody-drug-conjugate","label":"Antibody–drug conjugates"},{"articles":33,"id":"phagocytosis-checkpoint","label":"Phagocytosis checkpoints"},{"articles":32,"id":"nanoparticle","label":"Nanoparticles"},{"articles":22,"id":"oncolytic-virus","label":"Oncolytic viruses"}],"top_sites":[{"articles":705,"enrichment":4.06,"id":"leukaemia","label":"Leukemia"},{"articles":491,"enrichment":3.84,"id":"lymphoma","label":"Lymphoma"},{"articles":88,"enrichment":1.35,"id":"ovary","label":"Ovary"},{"articles":201,"enrichment":1.01,"id":"lung","label":"Lung"},{"articles":130,"enrichment":0.76,"id":"colorectal","label":"Colorectal"},{"articles":48,"enrichment":0.73,"id":"pancreas","label":"Pancreas"}],"trial_share":9.42,"trials":326,"years":[[1992,1],[1993,10],[1994,20],[1995,52],[1996,44],[1997,42],[1998,30],[1999,40],[2000,27],[2001,44],[2002,28],[2003,30],[2004,32],[2005,40],[2006,31],[2007,26],[2008,30],[2009,47],[2010,43],[2011,46],[2012,67],[2013,66],[2014,63],[2015,104],[2016,99],[2017,107],[2018,120],[2019,151],[2020,198],[2021,281],[2022,244],[2023,266],[2024,422],[2025,574],[2026,37]]},{"articles":1352,"growth":1.16,"id":"hifu","label":"High-intensity focused ultrasound","top_partners":[{"articles":37,"id":"nanoparticle","label":"Nanoparticles"},{"articles":26,"id":"electrochemical-therapy","label":"Electrochemical therapy"},{"articles":21,"id":"sonodynamic","label":"Therapeutic ultrasound (broad descriptor)"},{"articles":8,"id":"immunotherapy","label":"Immunotherapy"},{"articles":1,"id":"antibody-drug-conjugate","label":"Antibody–drug conjugates"},{"articles":1,"id":"car-t","label":"CAR T-cell / adoptive therapy"}],"top_sites":[{"articles":338,"enrichment":6.48,"id":"cervix/uterus","label":"Cervix / uterus"},{"articles":246,"enrichment":4.63,"id":"prostate","label":"Prostate"},{"articles":85,"enrichment":2.56,"id":"pancreas","label":"Pancreas"},{"articles":146,"enrichment":2.1,"id":"liver","label":"Liver"},{"articles":45,"enrichment":2.03,"id":"thyroid","label":"Thyroid"},{"articles":33,"enrichment":1.11,"id":"kidney","label":"Kidney"}],"trial_share":7.1,"trials":96,"years":[[2007,1],[2009,17],[2010,41],[2011,57],[2012,65],[2013,97],[2014,89],[2015,92],[2016,82],[2017,90],[2018,74],[2019,102],[2020,78],[2021,112],[2022,66],[2023,63],[2024,106],[2025,107],[2026,13]]},{"articles":15358,"growth":6.95,"id":"car-t","label":"CAR T-cell / adoptive therapy","note":"The mapping includes Receptors, Chimeric Antigen and the broader Immunotherapy, Adoptive descriptor. Counts include adoptive therapies beyond CAR T-cell therapy.","top_partners":[{"articles":512,"id":"immunotherapy","label":"Immunotherapy"},{"articles":377,"id":"bispecific-antibody","label":"Bispecific antibodies"},{"articles":230,"id":"crispr","label":"CRISPR gene editing"},{"articles":133,"id":"antibody-drug-conjugate","label":"Antibody–drug conjugates"},{"articles":131,"id":"oncolytic-virus","label":"Oncolytic viruses"},{"articles":116,"id":"nanoparticle","label":"Nanoparticles"}],"top_sites":[{"articles":2438,"enrichment":4.33,"id":"lymphoma","label":"Lymphoma"},{"articles":2284,"enrichment":2.99,"id":"leukaemia","label":"Leukemia"},{"articles":1216,"enrichment":1.86,"id":"skin/melanoma","label":"Skin / melanoma"},{"articles":297,"enrichment":1.14,"id":"kidney","label":"Kidney"},{"articles":742,"enrichment":1.0,"id":"brain/CNS","label":"Brain / central nervous system"},{"articles":265,"enrichment":0.92,"id":"ovary","label":"Ovary"}],"trial_share":6.64,"trials":1020,"years":[[1947,1],[1951,2],[1957,1],[1958,2],[1959,1],[1964,1],[1988,3],[1989,18],[1990,59],[1991,161],[1992,148],[1993,160],[1994,154],[1995,164],[1996,130],[1997,115],[1998,105],[1999,128],[2000,127],[2001,158],[2002,171],[2003,184],[2004,200],[2005,170],[2006,165],[2007,182],[2008,184],[2009,204],[2010,223],[2011,219],[2012,234],[2013,233],[2014,291],[2015,269],[2016,373],[2017,397],[2018,619],[2019,792],[2020,1009],[2021,1270],[2022,1298],[2023,1385],[2024,1635],[2025,1869],[2026,144]]},{"articles":5437,"growth":4.16,"id":"synthetic-lethality","label":"Synthetic lethality","top_partners":[{"articles":133,"id":"immunotherapy","label":"Immunotherapy"},{"articles":120,"id":"epigenetic","label":"Epigenetic processes & therapies"},{"articles":87,"id":"crispr","label":"CRISPR gene editing"},{"articles":36,"id":"nanoparticle","label":"Nanoparticles"},{"articles":35,"id":"antibody-drug-conjugate","label":"Antibody–drug conjugates"},{"articles":12,"id":"metabolic-targeting","label":"Metabolic targeting"}],"top_sites":[{"articles":1481,"enrichment":11.85,"id":"ovary","label":"Ovary"},{"articles":451,"enrichment":2.23,"id":"prostate","label":"Prostate"},{"articles":963,"enrichment":2.05,"id":"breast","label":"Breast"},{"articles":170,"enrichment":1.34,"id":"pancreas","label":"Pancreas"},{"articles":116,"enrichment":0.58,"id":"cervix/uterus","label":"Cervix / uterus"},{"articles":188,"enrichment":0.57,"id":"leukaemia","label":"Leukemia"}],"trial_share":6.29,"trials":342,"years":[[1976,1],[1980,2],[1982,2],[1983,6],[1984,5],[1985,7],[1986,6],[1987,5],[1988,13],[1989,9],[1990,16],[1991,5],[1992,5],[1993,5],[1994,6],[1995,12],[1996,6],[1997,7],[1998,7],[1999,7],[2000,14],[2001,5],[2002,11],[2003,16],[2004,12],[2005,22],[2006,20],[2007,31],[2008,36],[2009,69],[2010,92],[2011,134],[2012,130],[2013,117],[2014,141],[2015,146],[2016,220],[2017,279],[2018,267],[2019,348],[2020,435],[2021,503],[2022,537],[2023,499],[2024,551],[2025,607],[2026,63]]},{"articles":2515,"growth":0.81,"id":"electrochemical-therapy","label":"Electrochemical therapy","top_partners":[{"articles":64,"id":"car-t","label":"CAR T-cell / adoptive therapy"},{"articles":27,"id":"nanoparticle","label":"Nanoparticles"},{"articles":26,"id":"hifu","label":"High-intensity focused ultrasound"},{"articles":16,"id":"immunotherapy","label":"Immunotherapy"},{"articles":15,"id":"crispr","label":"CRISPR gene editing"},{"articles":11,"id":"sonodynamic","label":"Therapeutic ultrasound (broad descriptor)"}],"top_sites":[{"articles":225,"enrichment":4.0,"id":"pancreas","label":"Pancreas"},{"articles":480,"enrichment":3.8,"id":"skin/melanoma","label":"Skin / melanoma"},{"articles":271,"enrichment":2.31,"id":"liver","label":"Liver"},{"articles":144,"enrichment":1.6,"id":"prostate","label":"Prostate"},{"articles":60,"enrichment":1.19,"id":"kidney","label":"Kidney"},{"articles":103,"enrichment":0.71,"id":"colorectal","label":"Colorectal"}],"trial_share":5.65,"trials":142,"years":[[1993,5],[1994,13],[1995,14],[1996,13],[1997,14],[1998,22],[1999,21],[2000,38],[2001,45],[2002,35],[2003,51],[2004,47],[2005,66],[2006,66],[2007,65],[2008,97],[2009,80],[2010,82],[2011,86],[2012,111],[2013,116],[2014,127],[2015,136],[2016,135],[2017,122],[2018,126],[2019,134],[2020,140],[2021,118],[2022,89],[2023,87],[2024,93],[2025,110],[2026,11]]},{"articles":2513,"growth":5.28,"id":"sonodynamic","label":"Therapeutic ultrasound (broad descriptor)","note":"The source id is sonodynamic, but its Ultrasonic Therapy descriptor is broader than sonodynamic therapy. These are broad descriptor counts.","top_partners":[{"articles":310,"id":"nanoparticle","label":"Nanoparticles"},{"articles":21,"id":"hifu","label":"High-intensity focused ultrasound"},{"articles":21,"id":"immunotherapy","label":"Immunotherapy"},{"articles":11,"id":"electrochemical-therapy","label":"Electrochemical therapy"},{"articles":4,"id":"antibody-drug-conjugate","label":"Antibody–drug conjugates"},{"articles":3,"id":"car-t","label":"CAR T-cell / adoptive therapy"}],"top_sites":[{"articles":199,"enrichment":2.6,"id":"prostate","label":"Prostate"},{"articles":225,"enrichment":2.25,"id":"liver","label":"Liver"},{"articles":207,"enrichment":1.71,"id":"brain/CNS","label":"Brain / central nervous system"},{"articles":73,"enrichment":1.7,"id":"kidney","label":"Kidney"},{"articles":123,"enrichment":1.64,"id":"cervix/uterus","label":"Cervix / uterus"},{"articles":68,"enrichment":1.42,"id":"pancreas","label":"Pancreas"}],"trial_share":4.54,"trials":114,"years":[[1947,1],[1950,1],[1951,2],[1952,3],[1953,4],[1954,4],[1955,5],[1956,3],[1957,1],[1960,2],[1962,2],[1963,5],[1964,2],[1965,5],[1966,7],[1967,9],[1968,6],[1969,12],[1970,9],[1971,13],[1972,10],[1973,7],[1974,7],[1975,5],[1976,8],[1977,11],[1978,10],[1979,6],[1980,13],[1981,17],[1982,31],[1983,17],[1984,27],[1985,15],[1986,10],[1987,12],[1988,12],[1989,22],[1990,31],[1991,31],[1992,24],[1993,28],[1994,20],[1995,22],[1996,26],[1997,17],[1998,27],[1999,34],[2000,34],[2001,40],[2002,32],[2003,51],[2004,66],[2005,74],[2006,71],[2007,89],[2008,98],[2009,76],[2010,83],[2011,59],[2012,63],[2013,41],[2014,55],[2015,46],[2016,41],[2017,38],[2018,46],[2019,55],[2020,70],[2021,99],[2022,68],[2023,76],[2024,176],[2025,243],[2026,27]]},{"articles":31890,"growth":11.62,"id":"immunotherapy","label":"Immunotherapy","top_partners":[{"articles":517,"id":"nanoparticle","label":"Nanoparticles"},{"articles":512,"id":"car-t","label":"CAR T-cell / adoptive therapy"},{"articles":277,"id":"antibody-drug-conjugate","label":"Antibody–drug conjugates"},{"articles":263,"id":"oncolytic-virus","label":"Oncolytic viruses"},{"articles":236,"id":"epigenetic","label":"Epigenetic processes & therapies"},{"articles":235,"id":"bispecific-antibody","label":"Bispecific antibodies"}],"top_sites":[{"articles":7237,"enrichment":3.09,"id":"lung","label":"Lung"},{"articles":3740,"enrichment":2.13,"id":"skin/melanoma","label":"Skin / melanoma"},{"articles":954,"enrichment":1.81,"id":"bladder","label":"Bladder"},{"articles":1166,"enrichment":1.66,"id":"kidney","label":"Kidney"},{"articles":637,"enrichment":1.27,"id":"oesophagus","label":"Esophagus"},{"articles":1037,"enrichment":1.12,"id":"stomach","label":"Stomach"}],"trial_share":4.48,"trials":1430,"years":[[1992,2],[1993,1],[1994,1],[1995,9],[1996,8],[1997,10],[1998,12],[1999,11],[2000,12],[2001,15],[2002,24],[2003,22],[2004,35],[2005,55],[2006,48],[2007,59],[2008,91],[2009,86],[2010,110],[2011,109],[2012,145],[2013,191],[2014,246],[2015,464],[2016,741],[2017,1072],[2018,1378],[2019,1684],[2020,3102],[2021,4126],[2022,3898],[2023,3530],[2024,4762],[2025,5390],[2026,441]]},{"articles":5006,"growth":1.18,"id":"oncolytic-virus","label":"Oncolytic viruses","top_partners":[{"articles":263,"id":"immunotherapy","label":"Immunotherapy"},{"articles":131,"id":"car-t","label":"CAR T-cell / adoptive therapy"},{"articles":40,"id":"nanoparticle","label":"Nanoparticles"},{"articles":39,"id":"epigenetic","label":"Epigenetic processes & therapies"},{"articles":24,"id":"crispr","label":"CRISPR gene editing"},{"articles":22,"id":"bispecific-antibody","label":"Bispecific antibodies"}],"top_sites":[{"articles":674,"enrichment":2.91,"id":"brain/CNS","label":"Brain / central nervous system"},{"articles":236,"enrichment":2.59,"id":"pancreas","label":"Pancreas"},{"articles":516,"enrichment":2.51,"id":"skin/melanoma","label":"Skin / melanoma"},{"articles":145,"enrichment":1.61,"id":"ovary","label":"Ovary"},{"articles":271,"enrichment":1.42,"id":"liver","label":"Liver"},{"articles":64,"enrichment":1.04,"id":"bladder","label":"Bladder"}],"trial_share":4.02,"trials":201,"years":[[1954,2],[1956,1],[1957,2],[1958,1],[1959,2],[1960,5],[1961,1],[1962,2],[1963,1],[1964,4],[1965,6],[2003,1],[2004,2],[2005,55],[2006,147],[2007,163],[2008,199],[2009,214],[2010,240],[2011,193],[2012,294],[2013,258],[2014,213],[2015,271],[2016,237],[2017,232],[2018,248],[2019,248],[2020,294],[2021,326],[2022,245],[2023,242],[2024,314],[2025,319],[2026,24]]},{"articles":41278,"growth":0.91,"id":"epigenetic","label":"Epigenetic processes & therapies","note":"The mapping includes therapy descriptors and DNA Methylation, which also tags basic methylation biology. Counts include basic research as well as epigenetic treatments.","top_partners":[{"articles":236,"id":"immunotherapy","label":"Immunotherapy"},{"articles":120,"id":"synthetic-lethality","label":"Synthetic lethality"},{"articles":98,"id":"crispr","label":"CRISPR gene editing"},{"articles":97,"id":"nanoparticle","label":"Nanoparticles"},{"articles":66,"id":"metabolic-targeting","label":"Metabolic targeting"},{"articles":56,"id":"car-t","label":"CAR T-cell / adoptive therapy"}],"top_sites":[{"articles":4673,"enrichment":1.79,"id":"leukaemia","label":"Leukemia"},{"articles":4131,"enrichment":1.6,"id":"colorectal","label":"Colorectal"},{"articles":1610,"enrichment":1.36,"id":"stomach","label":"Stomach"},{"articles":3118,"enrichment":1.23,"id":"brain/CNS","label":"Brain / central nervous system"},{"articles":1123,"enrichment":1.14,"id":"ovary","label":"Ovary"},{"articles":655,"enrichment":1.03,"id":"oesophagus","label":"Esophagus"}],"trial_share":3.17,"trials":1307,"years":[[1964,2],[1965,1],[1972,14],[1973,13],[1974,14],[1975,19],[1976,15],[1977,19],[1978,14],[1979,10],[1980,11],[1981,25],[1982,28],[1983,20],[1984,58],[1985,49],[1986,40],[1987,41],[1988,27],[1989,35],[1990,27],[1991,27],[1992,34],[1993,37],[1994,26],[1995,34],[1996,57],[1997,195],[1998,174],[1999,240],[2000,319],[2001,482],[2002,586],[2003,802],[2004,915],[2005,1019],[2006,1113],[2007,1315],[2008,1330],[2009,1435],[2010,1642],[2011,1729],[2012,1966],[2013,2063],[2014,2209],[2015,2200],[2016,2093],[2017,2064],[2018,1971],[2019,2018],[2020,1958],[2021,1899],[2022,1521],[2023,1340],[2024,1812],[2025,2006],[2026,165]]},{"articles":380,"growth":null,"id":"microbiome","label":"Microbiome","top_partners":[{"articles":73,"id":"immunotherapy","label":"Immunotherapy"},{"articles":2,"id":"car-t","label":"CAR T-cell / adoptive therapy"},{"articles":2,"id":"epigenetic","label":"Epigenetic processes & therapies"},{"articles":1,"id":"nanoparticle","label":"Nanoparticles"}],"top_sites":[{"articles":72,"enrichment":4.58,"id":"colorectal","label":"Colorectal"},{"articles":31,"enrichment":2.27,"id":"skin/melanoma","label":"Skin / melanoma"},{"articles":26,"enrichment":2.04,"id":"liver","label":"Liver"}],"trial_share":3.16,"trials":12,"years":[[2015,8],[2016,4],[2017,4],[2018,20],[2019,28],[2020,24],[2021,45],[2022,36],[2023,30],[2024,58],[2025,109],[2026,14]]},{"articles":918,"growth":4.06,"id":"phagocytosis-checkpoint","label":"Phagocytosis checkpoints","top_partners":[{"articles":97,"id":"immunotherapy","label":"Immunotherapy"},{"articles":52,"id":"nanoparticle","label":"Nanoparticles"},{"articles":33,"id":"bispecific-antibody","label":"Bispecific antibodies"},{"articles":18,"id":"car-t","label":"CAR T-cell / adoptive therapy"},{"articles":11,"id":"oncolytic-virus","label":"Oncolytic viruses"},{"articles":10,"id":"crispr","label":"CRISPR gene editing"}],"top_sites":[{"articles":66,"enrichment":1.9,"id":"lymphoma","label":"Lymphoma"},{"articles":79,"enrichment":1.68,"id":"leukaemia","label":"Leukemia"},{"articles":28,"enrichment":1.58,"id":"ovary","label":"Ovary"},{"articles":59,"enrichment":1.46,"id":"skin/melanoma","label":"Skin / melanoma"},{"articles":26,"enrichment":1.45,"id":"pancreas","label":"Pancreas"},{"articles":73,"enrichment":1.36,"id":"lung","label":"Lung"}],"trial_share":1.42,"trials":13,"years":[[1994,1],[1995,3],[1996,1],[1997,1],[1999,3],[2000,4],[2001,1],[2002,2],[2003,2],[2004,5],[2005,6],[2006,1],[2007,3],[2008,3],[2009,7],[2010,6],[2011,12],[2012,15],[2013,22],[2014,16],[2015,33],[2016,35],[2017,39],[2018,36],[2019,61],[2020,60],[2021,71],[2022,98],[2023,105],[2024,121],[2025,134],[2026,11]]},{"articles":301,"growth":null,"id":"mrna-vaccine","label":"mRNA vaccines","top_partners":[{"articles":49,"id":"nanoparticle","label":"Nanoparticles"},{"articles":12,"id":"immunotherapy","label":"Immunotherapy"},{"articles":5,"id":"car-t","label":"CAR T-cell / adoptive therapy"},{"articles":3,"id":"oncolytic-virus","label":"Oncolytic viruses"},{"articles":2,"id":"crispr","label":"CRISPR gene editing"},{"articles":1,"id":"bispecific-antibody","label":"Bispecific antibodies"}],"top_sites":[{"articles":24,"enrichment":2.77,"id":"skin/melanoma","label":"Skin / melanoma"}],"trial_share":0.66,"trials":2,"years":[[2020,1],[2021,29],[2022,77],[2023,41],[2024,73],[2025,75],[2026,5]]},{"articles":8809,"growth":2.16,"id":"metabolic-targeting","label":"Metabolic targeting","top_partners":[{"articles":70,"id":"nanoparticle","label":"Nanoparticles"},{"articles":66,"id":"epigenetic","label":"Epigenetic processes & therapies"},{"articles":64,"id":"immunotherapy","label":"Immunotherapy"},{"articles":29,"id":"car-t","label":"CAR T-cell / adoptive therapy"},{"articles":25,"id":"crispr","label":"CRISPR gene editing"},{"articles":12,"id":"synthetic-lethality","label":"Synthetic lethality"}],"top_sites":[{"articles":724,"enrichment":1.98,"id":"liver","label":"Liver"},{"articles":319,"enrichment":1.82,"id":"pancreas","label":"Pancreas"},{"articles":226,"enrichment":1.31,"id":"ovary","label":"Ovary"},{"articles":560,"enrichment":1.24,"id":"colorectal","label":"Colorectal"},{"articles":755,"enrichment":1.16,"id":"breast","label":"Breast"},{"articles":587,"enrichment":1.12,"id":"lung","label":"Lung"}],"trial_share":0.51,"trials":45,"years":[[1946,1],[1948,7],[1949,3],[1950,6],[1951,9],[1952,5],[1953,4],[1954,6],[1955,4],[1956,12],[1957,13],[1958,19],[1959,15],[1960,20],[1961,21],[1962,20],[1963,24],[1964,32],[1965,58],[1966,48],[1967,51],[1968,62],[1969,51],[1970,58],[1971,40],[1972,52],[1973,30],[1974,36],[1975,26],[1976,43],[1977,37],[1978,30],[1979,37],[1980,23],[1981,26],[1982,23],[1983,31],[1984,23],[1985,24],[1986,28],[1987,23],[1988,24],[1989,24],[1990,27],[1991,18],[1992,25],[1993,20],[1994,12],[1995,17],[1996,21],[1997,24],[1998,21],[1999,13],[2000,18],[2001,15],[2002,27],[2003,27],[2004,31],[2005,35],[2006,52],[2007,70],[2008,79],[2009,86],[2010,135],[2011,149],[2012,210],[2013,270],[2014,312],[2015,377],[2016,392],[2017,399],[2018,437],[2019,518],[2020,607],[2021,670],[2022,540],[2023,438],[2024,682],[2025,816],[2026,90]]},{"articles":36788,"growth":2.49,"id":"nanoparticle","label":"Nanoparticles","top_partners":[{"articles":517,"id":"immunotherapy","label":"Immunotherapy"},{"articles":310,"id":"sonodynamic","label":"Therapeutic ultrasound (broad descriptor)"},{"articles":116,"id":"car-t","label":"CAR T-cell / adoptive therapy"},{"articles":111,"id":"crispr","label":"CRISPR gene editing"},{"articles":106,"id":"antibody-drug-conjugate","label":"Antibody–drug conjugates"},{"articles":97,"id":"epigenetic","label":"Epigenetic processes & therapies"}],"top_sites":[{"articles":3938,"enrichment":2.25,"id":"breast","label":"Breast"},{"articles":1576,"enrichment":1.6,"id":"liver","label":"Liver"},{"articles":1828,"enrichment":1.53,"id":"brain/CNS","label":"Brain / central nervous system"},{"articles":680,"enrichment":1.44,"id":"pancreas","label":"Pancreas"},{"articles":621,"enrichment":1.33,"id":"ovary","label":"Ovary"},{"articles":1699,"enrichment":1.2,"id":"lung","label":"Lung"}],"trial_share":0.49,"trials":182,"years":[[2004,3],[2005,18],[2006,110],[2007,298],[2008,392],[2009,519],[2010,727],[2011,889],[2012,1073],[2013,1288],[2014,1531],[2015,1693],[2016,1968],[2017,2140],[2018,2325],[2019,2653],[2020,2776],[2021,3000],[2022,2730],[2023,2507],[2024,3433],[2025,4218],[2026,497]]},{"articles":3674,"growth":8.13,"id":"crispr","label":"CRISPR gene editing","top_partners":[{"articles":230,"id":"car-t","label":"CAR T-cell / adoptive therapy"},{"articles":111,"id":"nanoparticle","label":"Nanoparticles"},{"articles":98,"id":"epigenetic","label":"Epigenetic processes & therapies"},{"articles":87,"id":"synthetic-lethality","label":"Synthetic lethality"},{"articles":85,"id":"immunotherapy","label":"Immunotherapy"},{"articles":25,"id":"metabolic-targeting","label":"Metabolic targeting"}],"top_sites":[{"articles":284,"enrichment":1.88,"id":"leukaemia","label":"Leukemia"},{"articles":87,"enrichment":1.53,"id":"ovary","label":"Ovary"},{"articles":146,"enrichment":1.21,"id":"liver","label":"Liver"},{"articles":209,"enrichment":1.21,"id":"lung","label":"Lung"},{"articles":67,"enrichment":1.16,"id":"pancreas","label":"Pancreas"},{"articles":233,"enrichment":1.09,"id":"breast","label":"Breast"}],"trial_share":0.16,"trials":6,"years":[[2014,12],[2015,70],[2016,141],[2017,276],[2018,356],[2019,416],[2020,437],[2021,484],[2022,236],[2023,223],[2024,405],[2025,569],[2026,49]]}],"sampling":{"passed":true,"runs":[{"accepted":1269,"attempts":8192,"ess":728.4053882422078,"passed":true,"seed":2026091911},{"accepted":1323,"attempts":8192,"ess":844.0587698053388,"passed":true,"seed":2026091912},{"accepted":1236,"attempts":8192,"ess":824.131112138982,"passed":true,"seed":2026091913}],"thresholds":{"maximum_heldout_rmse_median_span":0.02,"maximum_median_span_prior_fraction":0.05,"maximum_normalized_weight":0.02,"maximum_normalizer_relative_mcse":0.1,"maximum_tail_span_prior_fraction":0.1,"minimum_accepted":20,"minimum_ess":200.0,"normalizer_combined_mcse_multiplier":4.0}},"schema_version":1,"sites":[{"articles":380530,"id":"head and neck","label":"Head and neck"},{"articles":378191,"id":"breast","label":"Breast"},{"articles":304402,"id":"lung","label":"Lung"},{"articles":266602,"id":"leukaemia","label":"Leukemia"},{"articles":262866,"id":"colorectal","label":"Colorectal"},{"articles":257914,"id":"brain/CNS","label":"Brain / central nervous system"},{"articles":228568,"id":"skin/melanoma","label":"Skin / melanoma"},{"articles":212500,"id":"liver","label":"Liver"},{"articles":196557,"id":"lymphoma","label":"Lymphoma"},{"articles":162723,"id":"prostate","label":"Prostate"},{"articles":159782,"id":"cervix/uterus","label":"Cervix / uterus"},{"articles":120883,"id":"stomach","label":"Stomach"},{"articles":101620,"id":"pancreas","label":"Pancreas"},{"articles":100406,"id":"ovary","label":"Ovary"},{"articles":91118,"id":"kidney","label":"Kidney"},{"articles":68398,"id":"bladder","label":"Bladder"},{"articles":67705,"id":"thyroid","label":"Thyroid"},{"articles":65076,"id":"oesophagus","label":"Esophagus"}],"snapshot_date":"2026-09-21","sources":[{"path":"analysis/census-evidence-design.json","sha256":"adb0ced679f1d0a6088081373af309fd0066cd5951dad72bb0515ed7ef3028e6","url":"https://github.com/ELares/cancer_research/blob/main/analysis/census-evidence-design.json"},{"path":"analysis/census-mechanism-profile.json","sha256":"a405c24ec1921a3906e20b85adca54d62cd8ad640b01c50282e4554232597754","url":"https://github.com/ELares/cancer_research/blob/main/analysis/census-mechanism-profile.json"},{"path":"analysis/atlas-site-coverage.json","sha256":"5760b09f33d3d181e73291ae9134b5f4d902f5bf08207ae2242bbf73f4ab68b7","url":"https://github.com/ELares/cancer_research/blob/main/analysis/atlas-site-coverage.json"},{"path":"analysis/calibration/joint-resample-sampling.json","sha256":"6806657082d14f902bd698abb9c132e6b5ef87d44eaf9809f457c507b4c6765c","url":"https://github.com/ELares/cancer_research/blob/main/analysis/calibration/joint-resample-sampling.json"},{"path":"analysis/calibration/proposal-coverage-challenges.json","sha256":"6252872268d765da98485a4f36dac099ef1f4f2fd5883e846780bf334af04940","url":"https://github.com/ELares/cancer_research/blob/main/analysis/calibration/proposal-coverage-challenges.json"},{"path":"corpus/INDEX.jsonl","sha256":"3d95a430854f952cbdba297d0ef16b66e51daab5006d74eee60f7ad68e1de8ae","url":"https://github.com/ELares/cancer_research/blob/main/corpus/INDEX.jsonl"}]}